Alyx Woodward (obsolete) @Alyx@computerfairi.es

now for _Organic Syntheses_ roulette

first random word I'm trying..."dance"

wow that actually matched a few articles. the first match is one I've already hit recently (i was the oxazole synthesis using an amide of N-aminopyridine) so I'm rolling with the second one

http://orgsyn.org/demo.aspx?prep=v95p0097

an intriguing and rather simple reaction, intramolecular ring-closure of o-phenylbenzoic acid to 6H-benzo[c]chromen-6-one (the fundamental ring structure of "urolithins") using peroxydisulfate and AgNO3

(I feel inclined to twit Chara a bit about that one, seeing as how they work "determination" into conversation an average of three or four times a day)

🔴 I'm not THAT bad

yeah sure let's ask @KaylinEvergreen about that

trying to spot anything noteworthy in the _mise en scene_. one detail that stands out is that there's a big chart labelled "SPECTROSCOPY" on a wall, but it's taller than it's wide, which is not usually how visible-light spectra are shown on a chart. also it goes from pink to white to yellow, but I'll chalk that up to stylization (or simplification)

finally Prof. Rodgers offers the help of after-school tutoring to Lomax...if they have "some DETERMINATION"

dun dun DUN!

the conversation between Lomax and the teacher, Rodgers, continues

https://www.parallaxcomic.com/comic/page-08

still no definite answer about why Lomax is in classes they do badly at (do we know Lomax's gender at this point?) but they're hinting that parents aren't the reason. well, like I said last night, it's fair to assume there's some _exciting_ reason for Lomax forcing themselves through classes they suck at other than the obvious ones

oh pfft I typed "p. 6" when I'm on Page 7

whatever, just...add one in your head for the previous three toots

"but I didn't choose it" dun dun DUN!

I mean, pretty safe to guess Lomax's parents made the kid do it, but since this is a sci-fi webcomic I figure that the safe guess isn't the right guess

anyway of course Lomax sucks as a student (just like we all did!) and Rodgers sorrowfully suggests that Lomax has given up. Lomax tries to shrug it off: "oh I'm just not good at studying."

Rodgers: "but why are you a science major then"? oh, so this isn't high school? and there's only one science major at this college? "the science major" (well I think that's not unheard of actually, sounds like some Evergreen State College write-your-own-portfolio crap though)

bleh

fine, page 7

https://www.parallaxcomic.com/comic/page-07

so it's the talk alluded to at the end of the previous page, except there's a bit of confusion because the teacher, Rodgers, referred to Lomax as a "new kid" on page 5 but now he's talking about Lomax's grades as though he's been dealing with Lomax for a while. maybe he's just looking at the kid's record as a transfer student or something...eh, whatever, but it feels like a slight inconsistency

when Kara was much younger we had a PowerPC 6100 that also had a 486 PC in it running off a daughterboard. that thing was sweet

"are there any good FOSS android apps" shit of course not

yeah, I know, famous last words. this stuff is difficult!

ok realized my bio was kinda out of date and fixed it

think now with Chara (and Azzy and Frisk) firmly bonded, we're probably basically where we're gonna be, as a #pluralgang

well that's neat I guess! I'll try to remember this, if I ever have to make oxazoles...which seems a bit unlikely

in this particular _Organic Syntheses_ reaction, though, the 1,3-dipole is a strange beast indeed, an amide of N-aminopyridine, obtained by amidation of N-aminopyridinium iodide with the methyl ester of N-t-butoxycarbonylglycine. sticking a pyridinium group onto the amide nitrogen unbalances the usual charge distribution in the amide group and converts it to a 1,3-dipole, it would seem!

the "dipolarophile" is an unsymmetrical alkyne here. cycloaddition yields a substituted oxazole

in this class of reaction, a "dipolarophile", usually an asymmetrical alkene or alkyne, i.e. one with an electron-donating group on one side of the multiple bond and an electron-withdrawing group on the other side, reacts with a "1,3-dipole", a molecule that has a chain of three atoms and a definite difference in positive-negative polarity between the ends of the chain. to pick a very commonplace example, the so-called "click" reaction, the 1,3-dipole is an organic azide, R-N=N⁺=N⁻

ok didn't do my usual stuff yesterday. well, I'll do it right now

first, _Organic Synthesis_ roulette. and the word of the day to plug into the orgsyn.org search box is..."powder"

aw jeez it's a strange one

http://orgsyn.org/demo.aspx?prep=v95p0112

another "2+3 dipolar cycloaddition". this is a large class of chemical reactions, of particular use in synthesis of five-membered heterocycles