The base concept, I figure, is that we're still following the life of code page 437, character 002, the ubiquitous smiley face character. He's long out of work and still living in a single room apartment with no real furnishings. He doesn't know what happened to his neighbors, and the ostentatious castle next door that housed the dev team of the original game has been just a gravel lot for years.
His life has been quiet for 25 years. But suddenly, he hears The Programmer again.
The world has changed by immeasurably vast amounts. Number Two and the programmer barely know each other anymore. They've never been on the same page, but now it's unclear if they're even reading the same book.
It's a concept. I don't know if I have a real driving force to the story at all, or if it would be a stream of consciousness the way the original game ended up being. It bears more thinking, I guess.