"The downside is the unforgiving permadeath rogue-like nature of the game. Progress can become frustrating when you suddenly die and lose all your mutations and have to start again."
Yes, that's the genre you are playing.
The most negative review on Metacritic, which gives the game a 40, ends with, "As it stands, RAD will likely please roguelike aficionados who will forgive ill-conceived gameplay ideas because of the challenge it adds to the experience."
So it's basically saying, if you enjoy the genre, you will like it. But if you don't like the genre...you will not like it.
Thanks, very informative.
"On the other hand, the RNG can be brutal in how it distributes power-ups between runs"
Yeah, that's part of playing a rogue-like