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in which janine discovers there's no such thing as sleeping in on the weekends when you've got TWO pets clamoring to be fed now

shadowbringers spoilers (79 dungeon), bad bad joke 

well, based on crystal structure, it looks like vauthry's...................

.............

....................................pretty salty ( en.wiktionary.org/wiki/sodium_ )

*gently but firmly escorting a bug outside* you don't have to go home, but you can't stay here

in which janine discovers there's no such thing as sleeping in on the weekends when you've got TWO pets clamoring to be fed now

@InspectorCaracal @aldersprig and we're definitely getting to the point where it's becoming obvious that the statistics that have become standard have some major fuckin downsides that have gone unaddressed for *decades* because everyone's chasing the one true standard of crunching your numbers just-so

and this is where i with my english/bio degree and no stats class yell SMELL YA LATER NERDS, hop on my bike, rev it up, and then when the clouds dissipate am found laying dead on the ground,

@wigglytuffitout And don't get me started on differential diagnosis! "We still don't know what you have but we're pretty sure it's not any of these eighteen things so it's PROBABLY this."

"...but you should give more blood just in case."

@aldersprig SO MUCH OF MEDICINE IS JUST THROWING SHIT ON THE WALL TO SEE WHAT STICKS.

i mean i understand why most people don't wanna know that because it's definitely more comforting to say "oh yes, my doctor will know absolutely what to do, they understand this thoroughly now", but it's bonkers. it's guesses. the medicines we know exactly why and how they work are far outnumbered by the ones that work but we're not quite sure why.

(and this is one of the reasons medical animal testing and using model animals is SO IMPORTANT because WE JUST DUNNO MY DUDES, SHIT'S COMPLICATED, LET'S GO LOOK AT A ZEBRAFISH THEY GOT LESS MOVING PARTS)

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a truth of the world upsetting to many: a lot of medications exist in the realm of "well, we know this works in a percentage of people for this situation, so it's worth a go." "oh nice, how does it work?"

"we have absolutely no idea HOW it works still, just that it works"

so if you ever hear that like, the evil drug companies know an exact cure for something but won't let the public have it... .......................consider: we don't know a fucking thing my guy

medical fun fact 

@DialMforMara i may just be chattering your ear off now but i kind of hate anything that says "can you BELIEVE that SCIENCE has a CURE for x???" while neglecting to mention that... the situation is messy. it frustratingly promotes this conspiracy theory thinking that BIG PHARMA DOESN'T WANT YOU TO KNOW yada yada then you get people injecting their children with bleach.

it's important and great work done by this person! but... i wish they had actually memorialized *his work*

medical fun fact 

@DialMforMara came up with nothing statistically significant for it being used that way - clinicaltrials.gov/ct2/show/NC

i still don't quite know HOW pleconaril could affect hbc that dramatically, but it seems to negate it to the point where many complained of spotting and there were several unplanned pregnancies during the trial.

it's also not a 100% sure thing, and viruses can become resistant to pleconaril - ncbi.nlm.nih.gov/pmc/articles/

medical fun fact 

@DialMforMara w so it seems to be not really for all common colds, but for enteroviruses the drug prevents "the pH-mediated uncoating of the viral RNA" aka it getting at its own RNA to hijack the cell's machinery, thus stopping it from replicating. it works differently for rhinoviruses, binding to a certain receptor point. it also may work a third way entirely on another set of viruses.

it's still in trial via nasal spray but so far odds don't look good as the phase 2 trial>

medical fun fact 

@DialMforMara ah wait, i think i've found it - pleconaril is the stuff they're talking about.

>We also discovered that certain anti-rhinovirus drugs bound to a pocket in the capsid (26), a discovery that led to recognizing that the stable infectious virions were destabilized on binding to a receptor by ejecting a bound “pocket factor” molecule, thus initiating infection. ncbi.nlm.nih.gov/pmc/articles/

medical fun fact 

@DialMforMara @Canageek@cybre.space huh - i'd also like to know more information on this

presumably it's some type of antiviral, which works effectively across the many many many viruses that collectively are 'the common cold', and i'm not really aware of any antivirals that have such severe side effects - usually they tend to be efficacious antivirals by throwing a spanner in the works at a point that doesn't affect the rest of the body much.

well now i want to get Titania in warframe and blast Titania's theme from ffxiv over voice chat wherever i can ohno.gif

warframe fashion 

@irisjaycomics may i suggest blasting Titania's theme from the new ffxiv xpack at everyone on voice chat to really drive the point home? i'm just saying, falalalala kill some grineer is a very viable fashion look youtube.com/watch?v=saYCZ9jzLE

anyway, i think like 2 hours playing splatoon is probably enough

it's a game i enjoy but it is hard to do long sessions of because it is TENSE AND EXCITING and so i tense up my shoulders at which point they become Upset with me

so... time to chill and ffxiv

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