I'm replaying World of Goo and something I'm being reminded of real hard is that the most frustrating thing in a puzzle game is knowing exactly what you have to do to solve a level and the game's mechanics literally getting in the way of you being able to do so. So many levels I know how to solve, and quite a few I literally can't because the game is getting in my way.
World of Goo spoilers
For example, in Upper Shaft (one of the levels in Cog in the Machine), you have to carefully lower an explosive by using ivy goos in a somewhat specific manner. But so. fucking. often. I grab unattached goos when I'm trying to grab attached goos and, even more frustratingly, sometimes, I grab the one goo holding the whole thing up when I'm trying to grab a free goo. It's frustrating. I know how to solve it, but the game's getting in my way.
