One thing I wish spreadsheets could do better with: tags.
I have a table which records the magic the gathering cards I own. I record whether or not a card is foil, alternate art, borderless, etc.

This would be super easy to do if you could just put ad-hoc tags on a line of data. But because you can't: i need to have separate columns for every single different thing, even though it's literally just a yes/no situation.