I'm currently banging my head against a wall trying to figure out why some programs crash on launching. I suspect it's that I'm running Windows Server 2016 (based on the really old Windows 10 build 1607), but I'd rather not switch to Tiny10 because that's what we in the business call "a massive pain in the ass". But I can't confirm or deny that that's the reason because everyone just says the minimum requirement is "Windows 10 or higher".
Incidentally, this started because Dolphin versions newer than 5.0-17260 break. If anyone knows whether 5.0-16264 and newer made changes that would cause Server 2016 (which is, again, based off W10 build 1607] to not play nice with it, do let me know so I can bite that bullet sooner rather than later.