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Harp the Wigglytuff

@aldersprig SO MUCH OF MEDICINE IS JUST THROWING SHIT ON THE WALL TO SEE WHAT STICKS.

i mean i understand why most people don't wanna know that because it's definitely more comforting to say "oh yes, my doctor will know absolutely what to do, they understand this thoroughly now", but it's bonkers. it's guesses. the medicines we know exactly why and how they work are far outnumbered by the ones that work but we're not quite sure why.

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Harp the Wigglytuff

(and this is one of the reasons medical animal testing and using model animals is SO IMPORTANT because WE JUST DUNNO MY DUDES, SHIT'S COMPLICATED, LET'S GO LOOK AT A ZEBRAFISH THEY GOT LESS MOVING PARTS)

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Harp the Wigglytuff

a truth of the world upsetting to many: a lot of medications exist in the realm of "well, we know this works in a percentage of people for this situation, so it's worth a go." "oh nice, how does it work?"

"we have absolutely no idea HOW it works still, just that it works"

so if you ever hear that like, the evil drug companies know an exact cure for something but won't let the public have it... .......................consider: we don't know a fucking thing my guy

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Harp the Wigglytuff

medical fun fact 

@DialMforMara i may just be chattering your ear off now but i kind of hate anything that says "can you BELIEVE that SCIENCE has a CURE for x???" while neglecting to mention that... the situation is messy. it frustratingly promotes this conspiracy theory thinking that BIG PHARMA DOESN'T WANT YOU TO KNOW yada yada then you get people injecting their children with bleach.

it's important and great work done by this person! but... i wish they had actually memorialized *his work*

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Harp the Wigglytuff

medical fun fact 

@DialMforMara came up with nothing statistically significant for it being used that way - clinicaltrials.gov/ct2/show/NC

i still don't quite know HOW pleconaril could affect hbc that dramatically, but it seems to negate it to the point where many complained of spotting and there were several unplanned pregnancies during the trial.

it's also not a 100% sure thing, and viruses can become resistant to pleconaril - ncbi.nlm.nih.gov/pmc/articles/

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Harp the Wigglytuff

medical fun fact 

@DialMforMara w so it seems to be not really for all common colds, but for enteroviruses the drug prevents "the pH-mediated uncoating of the viral RNA" aka it getting at its own RNA to hijack the cell's machinery, thus stopping it from replicating. it works differently for rhinoviruses, binding to a certain receptor point. it also may work a third way entirely on another set of viruses.

it's still in trial via nasal spray but so far odds don't look good as the phase 2 trial>

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Harp the Wigglytuff

medical fun fact 

@DialMforMara ah wait, i think i've found it - pleconaril is the stuff they're talking about.

>We also discovered that certain anti-rhinovirus drugs bound to a pocket in the capsid (26), a discovery that led to recognizing that the stable infectious virions were destabilized on binding to a receptor by ejecting a bound “pocket factor” molecule, thus initiating infection. ncbi.nlm.nih.gov/pmc/articles/

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Harp the Wigglytuff

medical fun fact 

@DialMforMara @Canageek@cybre.space huh - i'd also like to know more information on this

presumably it's some type of antiviral, which works effectively across the many many many viruses that collectively are 'the common cold', and i'm not really aware of any antivirals that have such severe side effects - usually they tend to be efficacious antivirals by throwing a spanner in the works at a point that doesn't affect the rest of the body much.

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Harp the Wigglytuff

well now i want to get Titania in warframe and blast Titania's theme from ffxiv over voice chat wherever i can ohno.gif

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Harp the Wigglytuff

warframe fashion 

@irisjaycomics may i suggest blasting Titania's theme from the new ffxiv xpack at everyone on voice chat to really drive the point home? i'm just saying, falalalala kill some grineer is a very viable fashion look youtube.com/watch?v=saYCZ9jzLE

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Harp the Wigglytuff

@EeveeEuphoria don't forget to pick up a sewing machine at your gameboy peripherals shop too! kotaku.com/the-game-boy-sewing

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Harp the Wigglytuff boosted
Embers🎨🛡:ms_aromantic_flag:​

ah yes, a gameboy accessory that helped you...

...capture fish in real life

en.wikipedia.org/wiki/Game_Boy

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Harp the Wigglytuff

anyway, i think like 2 hours playing splatoon is probably enough

it's a game i enjoy but it is hard to do long sessions of because it is TENSE AND EXCITING and so i tense up my shoulders at which point they become Upset with me

so... time to chill and ffxiv

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Harp the Wigglytuff

here's also the blank without the writing on it, just in case uhhh... anyone in the / tags need

the 'you stop that' velma but with a splattershot and Pissed Off

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Harp the Wigglytuff

@Kaypar@snouts.online

i cant believe i actually opened photoshop to make this

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Harp the Wigglytuff boosted
a bug

Pearl Screamed at me During the Splatfest!! [NOT Clickbait]

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Harp the Wigglytuff boosted
Harp the Wigglytuff

since the last splatfest in is upon us, in the spirit of goodwill to all, may i remind/gift everyone with this playlist i made youtube.com/playlist?list=PLAO that is full of Extreme Power.

if you define extreme power as "what majima goro listens to at the gym", which of course we do,

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Harp the Wigglytuff boosted
acb

Jolene, the party game:

furtiveshambles.itch.io/jolene

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Harp the Wigglytuff

teams where everyone is running missiles and spams them constantly in splatoon:

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Harp the Wigglytuff

FIRST SPLATOON BATTLE I GET INTO IS A TEAM THAT'S PLAYING FOR THEIR 100X STREAK AND WE LOSE BY 20 POINTS

this_kills_the_squidkid.gif

(i'm glad i came in 2nd in team tho instead of dead last so i can feel like i did a contribute towards the goal instead of dooming them lmao)

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