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@softgoat it depends on the game - if the game required a lot of loading stuff from the hard drive (e.g. an open world game, or something with a lot of different models and textures), then there would be an amount of stress put on the HDD.
But if it didn't require much loading from the hard-drive (e.g. a procedurally generated game), then it would be fine.
@softgoat (but for the most part, you're just going to get some in-game slowness at worst - you're not going to do damage to your hardware, afaik)